Platform for Massive Screening of New Chemicals to Control Plant Pathogen

Platform for Massive Screening of New Chemicals to Control Plant Pathogen

Technology Description

Our biotechnological platform allows to identify, quantify and to determine the properties of a myriad of compounds (from synthetic or biological origin) in controlling relevant plant pathogenic fungi that cause economic losses worldwide. Selected substances, identified through this platform, may eventually become new tools for the control of this pathogen. With our technological development it is possible to discriminate if a substance/chemical compound (or in various combinations) leads to pathogen´s death, growth arrest, or if it only stops its overall metabolic activity. Our methodology allows non-invasive high throughput screenings by quantifying active growth and the pharmacokinetics properties of several compounds during numerous days, in real time.

Applications

Drug development
Drug discovery

Advantages

Allows evaluating the control properties of different compounds employing minimal quantities, and their effects in different biological tissues
Minimal time to obtain quantitative results
Low cost and high throughput

Stage of Development

We have obtained quantitative screening data for over 50 different chemical compounds including commercial fungicides and other extractives obtained from different biological sources, as for example botanical extracts
Measurements mechanisms and the whole platform is under validation process

Patent status

Under development

Inventors

Paulo Canessa, PhD
Facultad de Ciencias Biológicas

Dr. Paulo Canessa is a young scientist that has been involved in the molecular study of fungi for the last 10 years. With a good handle in molecular techniques, and quantitative studies of gene expression, he has been involved in fungal genome projects and the description of fungal homeostatic mechanisms. He has recently become an associated scientist at the Millennium Nucleus in Fungal integrative and Synthetic Biology, where he is leading one of the research areas associated with fungal pathogenesis. He has authored 13 ISI papers, with an H-index of 9.

Luis Larrondo, PhD
Facultad de Ciencias Biológicas

Dr. Luis Larrondo has over 15 years of experience working with diverse fungal species, with expertise in enzymology, molecular biology, genomics and molecular genetics. After being involved in several iconic fungal genome projects, he has become involved in transcriptional regulation studies in fungi, particularly in determining how these organisms sense and respond to the environment. Currently, he is the director of the Millennium Nucleus in Fungal integrative and Synthetic Biology, where part of his research program concentrates in developing synthetic circuits in fungi, innovative biotechnological applications, as well as the molecular dissection of circadian clocks. He has authored 40 ISI papers, with an H-index of 18, and over 2000 accumulated cites.

Possible partnership

In a first stage we are looking for high profile agrochemical companies to provide compounds to be tested in our platform in order to validate the technology (screening services will be provided on a free of cost basis and if the results of those tests are positive we will request in exchange to include that information in academic disclosures with the appropriate acknowledgements)

Second stage we will seek for investors interested in acquiring equity in a spinoff company that will be incorporated in order commercial exploit the technology.

For more information please contact

Magali Maida
Deputy Director – Office of Transfer and Development
Pontificia Universidad Catolica de Chile
e-mail: magali.maida@uc.cl
Phone: +56 2 2354 1041/skype: magali.maida

Patricia Anguita Mackay
Deputy Director – Innovation Projects
Fundación Copec-UC
e-mail: panguitm@uc.cl
Phone: +56 2 2354 2792/skype: patricia.anguita